So I figured if Becca did not really understand the whole thing and she lives with it as well as having had many different discussions regarding VRK1...others don't either. I am hoping a better understanding will be had by many after reading this post and perhaps parents can share with kids, so maybe, just maybe it will spare Becca from even one more child coming up to her with a comment such as "what do you have your brother's disease".
After doing some research on line, I went right to a reliable source...Dr. Julie Kaplan, a pediatric geneticists, and my wonderful cousin. I wanted a very simple or as simple a way as possible to be able to explain so here we go:
In order to discuss these types of inheritance, first some basic genetics. Genes are the blueprints that our bodies use to grow and function. Genes are carried on tiny structures called chromosomes that are found in every cell in our bodies. We have thousands of genes on 46 chromosomes, which come in pairs. The first 22 pairs are called autosomes. The 23rd pair is called the sex chromosomes. This pair determines if a child is a boy or a girl. Girls have two X chromosomes and boys have an X and a Y chromosome. For each pair of chromosomes, we receive one copy from our mother and one copy from our father.
One possible type of inheritance is autosomal recessive. In autosomal recessive conditions, both copies of the gene that causes the condition must have a change or mutation that causes them to not work correctly. Therefore, a child with a recessive condition must have inherited a non-working copy of the gene from each parent. The parents are called carriers because they have one non-working copy of the gene and one copy of the gene that works correctly. Because carriers have one working copy of the gene, they DO NOT have the condition. With each, pregnancy, there is a 25% change that both parents will pass on their non-working copy and the child will have the condition. There is a 50% chance that only one parent will pass on their non-working copy of the gene while the other parent passes on their working copy. In this case, the child will be a healthy carrier like the parents (BECCA). And, there is a 25% chance that both parents will pass on their working copies in which case the child will be healthy and will also not be a carrier.
|Take from the MDA Website|
I hope this is broken down enough for everyone to understand and those with children directly related to our children are willing to sit down and explain the process to their kids...Ian's disease is not contagious. You can touch him, visit our home, touch Becca, Brian or myself and you will NOT get it.